Fig. 1

RRM2 and NUSAP1 are highly expressed in PCa tumors and significantly correlated with poor clinical outcomes of PCa patients. Heatmaps show the top 20 upregulated or downregulated genes in GSE38241 (a), GSE3325 (b) and GSE104749 (c). d Venn diagram shows the crossed genes among two or three GEO datasets. e Diagram shows the risk factors (genes) along with the risk score. Risk factor analysis was performed based on the gene expression profile and overall survival data of patients from the TCGA_PRAD dataset, and 288 genes were identified as risk factors. f Venn diagram shows that RRM2 and NUSAP1 were two crossed genes among the 40 common genes from three GEO datasets and 288 risk factors from the TCGA_PRAD dataset. RRM2 and NUSAP1 were more highly expressed in PCa tumor samples than in normal samples in GSE38241 (g), GSE3325 (h) and GSE104749 (i). Analysis based on the TCGA_PRAD dataset shows that RRM2 and NUSAP1 are not only highly expressed in PCa tumors (j) but also correlated with tumor progression indexes, including T stage (k), N stage (l), Gleason score (m), overall survival (n and o) and progression-free survival (p and q) of PCa patients. ns indicates not significant, * indicates p < 0.05, ** indicates p < 0.01, *** indicates p < 0.001