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Fig. 10 | Journal of Experimental & Clinical Cancer Research

Fig. 10

From: LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network

Fig. 10

Proposed model of SNHG4 driving prostate cancer progression and enzalutamide resistance. SNHG4 regulates the cell cycle, cell senescence, DNA damage repair, cell proliferation and enzalutamide resistance by modulating RRM2, EZH2, AURKA and TK1 through a let-7 miRNA-mediated ceRNA regulatory network. In addition, RREB1 activates the transcription of SNHG4 and is regulated by the SNHG4/let-7/RREB1 feedback loop

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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