Fig. 6

Targeting Tnfaip2 promotes the cisplatin treatment effect in vivo. (a) Schematic diagram of 4NQO-induced HNSCC in C57BL/6 mice. (b-c) Representative visible lesion images (b) and lesion area quantification (c) in different treatment groups. (d) Representative TUNEL fluorescence staining images and apoptosis percentage quantification in different treatment groups. (e) Representative H&E staining and invasion grade quantification in different treatment groups. (f) Analyses of GSH/GSSG and SOD in different treatment groups. (g-h) IHC staining for TNFAIP2, NRF2, HO1 and NQO1 (g) and quantification (h) in different treatment groups. Scale bars, 100 μm. Data are presented as the mean ± SEM. n.s., not significant; * P < 0.05; ** P < 0.01; *** P < 0.001