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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC

Fig. 8

Mechanism diagram. P300 and the transcription factor SP1 form a complex that binds to the promoter region of the METTL1 gene to regulate its transcriptional activation, leading to aberrant high METTL1 expression in CRPC. Furthermore, METTL1 protects CDK14 mRNA from degradation by adding m7G modifications within it and ultimately leading to CRPC progression

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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