Fig. 1

MKRN1 is highly expressed and associated with poor prognosis in patients with CRC. A The expression distribution of mRNA in different tumour cell lines. B The distribution of MKRN1 expression in tumour and normal tissues. C MKRN1 expression in CRC tumour and adjacent non-tumour tissues was verified by WB analysis. D Immunohistochemistry detection of MKRN1 expression in tissue sections of patients with CRC and colitis showing typical photographs (scale bars are 100 and 50 µm, respectively). E The Kaplan–Meier Plotter in the R2 Genomics Analysis Platform was used to draw the overall survival curve. F WB analysis of MKRN1 expression levels in CRC cells (HT29, HCT116, HCT15, and RKO) and normal human colonic fibroblasts (CCD-18Co). ** P < 0.01, *** P < 0.001