Fig. 1

SENP5 was correlated radioresistance in colorectal cancer. A Expression of SENP5 in colorectal cancer tissues and normal tissues of CRC patients. These data were acquired from UALCAN (http://ualcan.path.uab.edu) B Kaplan-Meier survival analysis SENP5 high expression and low expression in Colorectal cancer (CRC) patients derived from TCGA database (log-rank p = 0.0018). These data were acquired from GEPIA2 (http://gepia2.cancer-pku.cn). C-D IHC staining and quantitative analysis of SENP5 in LARC cancer tissues with different radiosensitivity based on tumor regression grades (Radiosensitive, TRG = 0–1, Radioresistant, TRG = 3). *P < 0.05 Vs the TRG0-1 group. E Kaplan-Meier survival analysis of SENP5 in LARC patients received radiotherapy. F SENP5 mRNA expression in radiosensitive and radioresistant patients measured by RT-PCR assay. G The mRNA expressions of SENP5 in normal intestine and CRC cell lines. H Colony formation analysis of celluar radiosensitivity in CRC cells with high Vs low SENP5 expressions. ****P < 0.0001 Vs survival in SW480 cells