Fig. 9From: MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastomaFinal model. Schematic model showing the impact of THZ531-mediated inhibition of CDK12/13 on the RNAPII processivity and the expression of DDR genes in MYC-dependent manner; Abbreviation: TSS (transcription start site), TES (transcription end site), AAA (poly(A) tail)Back to article page