Fig. 5

circGUCY1A2 is a potential therapeutic target. A Representative images of the tumor bearing BALB/c nude mice and xenograft tumors. B The relative volumes of the tumors in the circGUCY1A2 groups and control groups. C Tumor growth curves of subcutaneous implantation models of NSCLC. D Representative images of HE and immunohistochemical staining for TUNEL and Ki67 expression in tumor tissues (original magnification: 200×). E Representative images of tumor bearing nod/scid mice PDX model tumors. F circGUCY1A2 expression of PDX model tumors. G Growth curves of PDX model tumors. H Immunohistochemistry staining of PTEN, Ki67, TUNEL, cleaved-caspase 3 and Bax. NC: negative control (original magnification: 200× and 400×). Ns: no significance, *P < 0.05, **P < 0.01, ***P < 0.001. Error bars indicate the S.E.M