Table 1 Differences in basal- or cytokine-stimulated phospho-protein levels in cancer patients’ peripheral immune cells compared to healthy donors
Cancer type | Signaling pathway | Cell type | Increased or decreased in cancer patients vs healthy donors | Reference |
|---|---|---|---|---|
Melanoma | IFNα – p-STAT1(Y701) | Lymphocytes | Decreased | [17] |
Breast | IFNα – p-STAT1(Y701) | T cells, B cells, NK cells | Decreased | [18] |
IFNγ – p-STAT1(Y701) | B cells | Decreased | ||
Gastrointestinal | IFNα – p-STAT1(Y701) | T cells, B cells | Decreased | |
IFNγ – p-STAT1(Y701) | B cells | Decreased | ||
Melanoma | IFNα – p-STAT1(Y701) | T cells, B cells | Decreased | |
IFNγ – p-STAT1(Y701) | B cells | Decreased | ||
Breast | IL-6 p-STAT1(Y701) | CD4+ naïve T cells | Decreased | [19] |
IL-6 p-STAT3(Y705) | CD4+ naïve T cells | Decreased | ||
Hepatocellular | p-STAT3(Y705) | CD4+ and CD8+ T cells | Increased | [20] |
Breast | IL-7 p-STAT5(Y694) | CD4+ and CD8+ T cells | Decreased | [21] |