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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: CHSY1 promotes CD8+ T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening

Fig. 7

CHSY1 affect PD—L1 expression and cause of CRC liver metastasis through SDH/succinate/PI3K/AKT/HIF1A pathways. A Determination results of succinic acid content in each group of samples. B Determination results of SDH concentration in each group of samples. C Western blotting results of the expression of P-PI3K, P-AKT, HIF1A and PD-L1 in different groups. D, E The JASPAR database predicted that the PD-L1 gene promoter covered the HIF1A binding site. F ChIP data of GSE85096 and GSE85096 showed that HIF1A has a prominent peak upstream of PD-L1. *, P < 0.05; **, P < 0.01; ***, P < 0.001

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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