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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: CHSY1 promotes CD8+ T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening

Fig. 8

PLGA-loaded Artemisinin and ICG probe as a CHSY1 inhibitor can reduce liver metastasis and enhance the effect of anti-PD1 in CRC liver metastasis. A DLS potential of Artemisinin-coupled fluorescence on PLGA. B Zeta potential of Artemisinin-coupled fluorescence on PLGA. C PLGA-loaded Artemisinin coupled fluorescence display. D Fluorescence imaging of PLGA loaded Artemisinin with ICG probe. E Metabolic distribution of PLGA-loaded Artemisinin-linked ICG probe in mice. F Images of liver metastases in each group. G Analysis of liver metastases tumors in the respective groups. (H-I) The immunofluorescence was used to detect the expression of CHSY1 and PD-L1 in liver metastases in each group.*, P < 0.05; **, P < 0.01; ***, P < 0.001;****, P < 0.0001.ns indicates no statistical difference

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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