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Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: CHSY1 promotes CD8+ T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening

Fig. 9

Pattern diagram showing that CHSY1 could promote CD8+ T cell exhaustion by activating the succinate metabolism pathway leading to CRC liver metastasis based on CRISPR/Cas9 results.The combination of CHSY1 knockdown and anti-PD1 contributed to synergistic resistance against liver metastasis in CRC. Artemisinin could significantly inhibit the activity of CHSY1, and the combination of anti-PD1 can synergistically treat CRC liver metastasis. PLGA-loaded Artemisinin-linked ICG probe further improves the therapeutic effect of Artemisinin and realizes the visualization of drug metabolism in vivo

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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