CHSY1 promotes CD8+ T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening

Table 1 Clinical characteristics of 54 patients with CRC

Characteristic	Total (cases [%])	CHSY1 expression (cases [%])		P value
Characteristic	Total (cases [%])	Low (n = 32)	High (n = 22)	P value
Age				0.295
< 65 years	21	11	10
≥ 65 years	33	21	12
Gender				0.205
Male	32	17	15
Female	22	15	7
Tumor size				0.520
< 5 cm	28	17	11
≥ 5 cm	26	15	11
Differentiation				0.684
High-middle	10	6	4
Low	44	26	18
TNM stage				< 0.001
I-II	33	29	4
III-IV	21	3	18
Lymph node metastasis				< 0.001
Absent	32	29	4
Present	22	3	18

ISSN: 1756-9966