Fig. 3

PDTO are highly compacted 3D multicellular structures and display key ultrastructural features of OCCC such as the PDX. A Scanning electron micrograph of PDTO derived from the tumor patient (upper panel) or derived from the PDX (lower panel). Scale bar: 20 µm. B Transmission electron microscopy images of the PDX (top row), the PDTO derived from the patient tumor (middle row), and the PDTO derived from the PDX (bottom row). Red arrow, microvilli; blue arrow, lipid droplet; orange arrow, glycogen; green arrow, alveolar structure. Scale bar: 1 µm