Fig. 7From: RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic LeukemiaIGF2BP1 and ETV6::RUNX1 promote progenitor expansion in the mouse bone marrow A) Bone marrow cell counts showing significantly high numbers in the combination group expressing ETV6::RUNX1 and IGF2BP1 B) Double positive (GFP+ mCherry+) ratio in the bone marrow and representative FACS plots showing clonal expansion C)-F), Quantitation (percentage and absolute counts) of Lineage negative cells, Hematopoietic stem cells, lymphoid-primed multi-potential progenitors, common lymphoid progenitors in the bone marrow of the mice belonging to different groups at 16 weeks after bone marrow transplant with representative FACS plots (n= 8 in each group; t-test; p * <0.05, ** <0.01, *** <0.005, **** <0.0001)Back to article page