Fig. 1

Comprehensive characterization of GBM patients and their sibling GSCs lines. Integrated matrix of tissue samples from grade IV glioma patients (Tex; blue) and GSCs lines (GSCs; red) across subtypes reporting gene variants (indels, SNVs, splicing, stopgain) together with significant CNVs and allelic frequencies (loss of heterozygosity; LOH, amplification, deletion, duplication, mosaicisms). For each single sample, columns represent number and type of genetic alterations. Genetic variations are reported according to their frequency in GBM tissues and their GSCs (% samples with mutations and % samples with CNVs). The status of IDH1 and TERT promoter genes and the presence of EGFRvIII is also depicted