Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies

Visioli, Alberto; Trivieri, Nadia; Mencarelli, Gandino; Giani, Fabrizio; Copetti, Massimiliano; Palumbo, Orazio; Pracella, Riccardo; Cariglia, Maria Grazia; Barile, Chiara; Mischitelli, Luigi; Soriano, Amata Amy; Palumbo, Pietro; Legnani, Federico; DiMeco, Francesco; Gorgoglione, Leonardo; Pesole, Graziano; Vescovi, Angelo L.; Binda, Elena

doi:10.1186/s13046-023-02811-0

Journal of Experimental & Clinical Cancer Research

Table 1 Clinical characteristics of patients included in this study

From: Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies

ID Sample	SampleType^a	Subtype	Sex	Age	Clinic.OS_days	Clinic.IDH1	EGFRvIII	TERT Promoter	Clinic.Pathology
GBM#28	TS	PRONEURAL	M	69	DEATH	WT	NO	C228T	GBM
GBM#40	TS/NS	PRONEURAL	F	55	DEATH	WT	NO	C228T	GBM
GBM#21	TS	PRONEURAL	M	50	DEATH	WT	NO	WT	GBM
GBM#22	TS	PRONEURAL	M	61	DEATH	WT	NO	C228T	GBM
GBM#46	TS/NS	PRONEURAL	F	56	DEATH	WT	NO	C250T	GBM
GBM#38	TS	PRONEURAL	F	61	DEATH	WT	YES	C250T	GBM
GBM#39	TS	PRONEURAL	M	60	DEATH	WT	NO	WT	GBM
GBM#49	TS/NS	PRONEURAL	F	62	DEATH	WT	NO	C228T	GBM
GBM#62	TS/NS	PRONEURAL	M	70	DEATH	WT	NO	C228T	GBM
GBM#52	TS/NS	PRONEURAL	F	72	DEATH	WT	YES	C228T	GBM
GBM#56	TS/NS	PRONEURAL	M	61	DEATH	WT	NO	C228T	GBM
GBM#3	NS	PRONEURAL	M	73	DEATH	WT	NO	C228T	GBM
GBM#2	NS	PRONEURAL	M	61	DEATH	WT	NO	C228T	GBM
GBM#20	TS	PRONEURAL	F	83		WT	NO		GBM
GBM#93	NS	PRONEURAL	M	50	DEATH	WT	NO	WT	GBM
GBM#6	TS/NS	CLASSICAL	M	60		WT	NO	C228T	GBM
GBM#32	TS	CLASSICAL	M	43	DEATH	WT	YES	WT	GBM
GBM#1	NS	CLASSICAL	M	78	DEATH	WT	NO	C228T	GBM
GBM#45	NS	CLASSICAL	M	72		WT	NO	C228T	GBM
GBM#8	TS	CLASSICAL	F	63	DEATH	WT	YES	C228T	GBM
GBM#11	TS	CLASSICAL	M	63	DEATH	WT	YES	C228T	GBM
GBM#10	TS	CLASSICAL	M	75	DEATH	WT	NO	WT	GBM
GBM#25	TS	CLASSICAL	F	63		WT	YES	C228T	GBM
GBM#17	TS	CLASSICAL	M	53	DEATH	WT	NO	C228T	GBM
GBM#34	TS	CLASSICAL	F	74	DEATH	WT	NO	C250T	GBM
GBM#7	TS	CLASSICAL	F	47		WT	YES	C228T	GBM
GBM#12	TS	CLASSICAL	M	42	DEATH	WT	NO	C228T	GBM
GBM#13	TS	CLASSICAL	M	42	DEATH	WT	YES	C250T	GBM
GBM#29	TS	CLASSICAL	F	62	ALIVE	WT	NO	C228T	GBM
GBM#14	TS	CLASSICAL	M	77	DEATH	WT	YES	C228T	GBM
GBM#30	TS	CLASSICAL	M	52	DEATH	WT	NO	C228T	GBM
GBM#19	TS	CLASSICAL	F	56	DEATH	WT	YES	C228T	GBM
GBM#35	TS	CLASSICAL	M	67	DEATH	WT	NO	C228T	GBM
GBM#36	TS	CLASSICAL	M	72	DEATH	WT	NO	C228T	GBM
GBM#47	TS/NS	CLASSICAL	M	79	DEATH	WT	NO	C228T	GBM
GBM#58	TS/NS	CLASSICAL	F	63	DEATH	WT	YES	C228T	GBM
GBM#60	TS/NS	CLASSICAL	M	54	ALIVE	WT	YES	C228T	GBM
GBM#61	TS/NS	CLASSICAL	F	75	DEATH	WT	YES	C228T	GBM
GBM#59	TS/NS	CLASSICAL	F	59	DEATH	WT	NO	WT	GBM
GBM#50	TS/NS	CLASSICAL	M	76	DEATH	WT	YES	C228T	GBM
GBM#67	TS/NS	CLASSICAL	M	44	DEATH	WT	YES	C250T	GBM
GBM#27	TS	CLASSICAL	F	69		WT	NO		GBM
GBM#51	TS/NS	CLASSICAL	M	79	ALIVE	WT	YES	C228T	GBM
GBM#65	TS/NS	CLASSICAL	M	45	DEATH	WT	NO	WT	GBM
GBM#64	TS/NS	CLASSICAL	F	46	DEATH	WT	YES	C228T	GBM
GBM#66	TS/NS	CLASSICAL	F	44	DEATH	WT	NO	C250T	GBM
GBM#4	NS	CLASSICAL	F	79	DEATH	WT	NO	C228T	GBM
GBM#16	TS	CLASSICAL	M	58	DEATH	WT	NO	C250T	GBM GIANT
GBM#9	TS	CLASSICAL	F	65		WT	YES	C228T	GBM
GBM#70	TS	CLASSICAL	M	79	DEATH	WT	YES	C228T	GBM
GBM#71	TS	CLASSICAL	F	37	DEATH	WT	YES	WT	GBM
GBM#72	TS	CLASSICAL	M	74	DEATH	WT	NO	C228T	GBM
GBM#74	TS	CLASSICAL	F	64	DEATH	WT	YES	WT	GBM
GBM#79	TS	CLASSICAL	M	43	DEATH	WT	YES	C228T	GBM
GBM#80	TS	CLASSICAL	M	41	ALIVE	WT	YES	C228T	GBM
GBM#81	TS	CLASSICAL	M	75	DEATH	WT	NO	C250T	GBM
GBM#83	TS	CLASSICAL	M	39	DEATH	WT	NO	C250T	GBM
GBM#84	TS	CLASSICAL	M	50	DEATH	WT	YES	C228T	GBM
GBM#85	TS	CLASSICAL	M	53	DEATH	WT	YES	WT	GBM
GBM#87	TS	CLASSICAL	M	57	DEATH	WT	NO	C228T	GBM
GBM#88	TS	CLASSICAL	F	58	DEATH	WT	YES	C228T	GBM
GBM#89	TS	CLASSICAL	M	67	DEATH	WT	YES	C228T	GBM
GBM#91	TS	CLASSICAL	M	67	DEATH	WT	YES	C250T	GBM
GBM#92	TS	CLASSICAL	M	66	DEATH	WT	NO	C228T	GBM
GBM#31	TS	MESENCHYMAL	F	69	DEATH	WT	YES	C228T	GBM
GBM#33	TS	MESENCHYMAL	M	77	DEATH	WT	NO	C250T	GBM
GBM#23	TS	MESENCHYMAL	M	72	DEATH	WT	NO	C250T	GBM
GBM#41	TS/NS	MESENCHYMAL	F	77	DEATH	WT	NO	C228T	GBM
GBM#26	TS	MESENCHYMAL	F	63		WT	NO	C250T	GBM
GBM#15	TS	MESENCHYMAL	M	62	DEATH	WT	NO	WT	GBM GIANT
GBM#42	TS/NS	MESENCHYMAL	F	51	DEATH	WT	NO	C250T	GBM
GBM#24	TS	MESENCHYMAL	M	41	DEATH	WT	NO	C250T	GBM
GBM#18	TS	MESENCHYMAL	M	60	DEATH	WT	NO	C228T	GBM
GBM#43	TS/NS	MESENCHYMAL	F	43	DEATH	WT	NO	C228T	GLIOSARCOMA
GBM#44	TS/NS	MESENCHYMAL	M	10	DEATH	WT	NO	WT	GBM GIANT
GBM#37	TS	MESENCHYMAL	M	64	DEATH	WT	NO	C228T	GBM
GBM#48	TS/NS	MESENCHYMAL	M	38	DEATH	WT	NO	C250T	GBM
GBM#63	TS/NS	MESENCHYMAL	M	50	DEATH	WT	NO	C228T	GBM
GBM#53	TS/NS	MESENCHYMAL	M	70	DEATH	WT	NO	C228T	GBM
GBM#54	TS/NS	MESENCHYMAL	M	41	DEATH	WT	NO	C228T	GBM
GBM#55	TS/NS	MESENCHYMAL	M	55	DEATH	WT	NO	C228T	GBM
GBM#57	TS/NS	MESENCHYMAL	M	69	DEATH	WT	NO	C228T	GBM
GBM#5	TS/MS	MESENCHYMAL	F	71	DEATH	WT	NO	C250T	GBM
GBM#90	TS	MESENCHYMAL	M	56	DEATH	WT	NO	C228T	GBM
GBM#68	TS	MESENCHYMAL	M	50	DEATH	WT	NO	C228T	GBM
GBM#69	TS	MESENCHYMAL	F	72	DEATH	WT	NO	C228T	GBM
GBM#73	TS	MESENCHYMAL	M	80	DEATH	WT	NO	C228T	GBM
GBM#75	TS	MESENCHYMAL	M	65	ALIVE	MUT	NO	WT	GBM GIANT
GBM#76	TS	MESENCHYMAL	M	63	DEATH	WT	NO	WT	GBM
GBM#77	TS	MESENCHYMAL	F	69	DEATH	WT	NO	C228T	GBM
GBM#78	TS	MESENCHYMAL	M	51	DEATH	WT	NO	C228T	GBM
GBM#82	TS	MESENCHYMAL	F	48	DEATH	WT	NO	C228T	GBM
GBM#86	TS	MESENCHYMAL	M	55	DEATH	WT	NO	C228T	GBM

^aTS Tissue and NS Neurosphere

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ISSN: 1756-9966

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