Fig. 8

circRNF10/ZBTB48/IGF2BP3 feedback loop regulates GBM tumor burden in vivo. a Representative photographs showed the sizes of intracranial tumors in the coronal position of the circRNF10 knockdown group and combined with ZBTB48, HSPB1 overexpression and Fer-1 treatment groups. Scale bar = 1 mm. b Representative immunohistochemical images showed the staining and expression of ZBTB48, HSPB1, IGF2BP3 and Ki-67 of the multiple groups mentioned above. Scale bar = 50 μm. c The quantified staining results of Ki-67, ZBTB48, HSPB1and IGF2BP3 according to the German IHC scoring system (GIS). d The tumor sizes of different groups mentioned above. e Kaplan–Meier survival curves illustrates the survival times of NOD/SCID mice of different mentioned groups. f Schematic diagram showing circRNF10/ZBTB48/IGF2BP3 feedback loop promotes glioma tumorigenesis via HSPB1 mediated ferroptosis defending and MKRN3 inhibition. All data are expressed as the mean ± SD (three independent experiments). *p < 0.05; **p < 0.01; ***p < 0.001; ns, no significance