Fig. 2

UGDH expression in ovarian cancer histotypes. Representative images of UGDH expression in high grade serous ovarian cancers that were scored as (A) Negative, B Low, C Moderate or (D) Strong, for both cytoplasmic and nuclear localization. E Proportions of staining scores for cytoplasmic and nuclear expression of UGDH in primary tumors and (F) metastases. G Survival analysis of HGS cancers comparing low versus high cytoplasmic UGDH. H Survival analysis of HGS cancers comparing low versus high nuclear UGDH. I Progression-free survival analysis of HGS cancers comparing low versus high cytoplasmic UGDH. J Progression-free survival analysis of HGS cancers comparing low versus high nuclear UGDH. K Clear cell, Stage 3C, top left panel H&E in 4X, top right panel IHC in 4X, lower panel IHC 20x, L Endometrioid, stage 3C, top left panel H&E in 4X, top right panel IHC in 4X, lower panel IHC 20x. M Mucinous Stage 3C top left panel H&E in 4X, top right panel IHC in 4X, lower panel IHC 20x. N Expression of UGDH expressed as H-score. Scale bar is 200 µm