Fig. 1

CCAT1 is highly expressed in the tissues, cells, serums and plasma exosomes of GC. A, B The GEPIA and C Lnc2cancer 3.0 database showed that the expression of CCAT1 was increased in GC tissues and was closely related with pathologic stages. D The expression of CCAT1 was significantly upregulated in our cohort of patients with GC (N = 90). E Kaplan–Meier analysis indicated a decreased overall survival for GC patients with high CCAT1 expression (N = 90). F GEPIA database manifested that high expression of CCAT1 was significantly associated with a shorter disease-free survival in patients with GC. G Compared to GES-1 cells, the expression of CCAT1 was elevated in GC cell lines. H The expression of CCAT1 was augmented in exosomes derived from GC cells compared to those isolated from GES-1 cells. I The expression of CCAT1 was enhanced in serums and J plasma exosomes derived from GC patients compared to that in HD. K The ROC curve showed the diagnostic proficiency of CCAT1 in plasma exosomes for GC. All data are presented as the mean values ± SD from three independent experiments. Statistical comparisons were conducted using Wilcoxon matched-pairs signed rank test (D), One-Way ANOVA (G and H), Mann–Whitney test (I) and Unpaired t-test with Welch's correction (J). ^*p < 0.05, ^**p < 0.01