Fig. 4

CCAT1 facilitates the growth of GC cells in vivo. A Compared to the control group, the tumor size, B growth rate and C weight were decreased in nude mice of the sh-CCAT1 group. D IHC staining results showed that expression of LDHA, HK2, PKM2, PTBP1, Ki-67, N-cadherin, and Vimentin was significantly attenuated, and the level of PKM1 and E-cadherin was elevated in tumor tissues of the sh-CCAT1 group (Scale bars = 50 µm). Data are represented as mean values ± SD. Statistical significance of differences between mean values was assessed with 2-way ANOVA with Multiple comparisons (B), Unpaired t-test (C) and Multiple Mann–Whitney tests (D). Each circle represents an animal. ^**p < 0.01