Fig. 9
From: LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement
Mechanistic scheme of CCAT1 in GC. CCAT1 interacted with PTBP1 to maintain its stability by impeding the ubiquitin-mediated degradation. As a result, CCAT1 facilitated the expression of HK2 and LDHA, induced a switch from PKM1 to PKM2 isoform, led to an enhancement of glycolysis and ultimately promoted the proliferation, migration and invasion of GC cells