Fig. 1

Initiation of autochthonous mammary tumors in cancer-prone mice is not dependent on xCT. A Percentage of disease free-survival and B tumor multiplicity from disease onset in BALB-neuT/xCT^wt (WT) and BALB-neuT/xCT^null (null) mice. C Percentage of mice affected by lung metastasis at sacrifice. Numbers of mice are reported in the panel legends. Statistical analysis: Log-rank (Mantel-Cox) test (panel A), unpaired t test (panel B), or Fisher’s exact test (panel C). Where not indicated, p value is not significant. In some instances, p values are represented in numbers when not significant. In panel B, mean values ± SD are depicted