Fig. 8From: Gastric cancer-derived LBP promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formationThe schematic diagram of GC-derived LBP promoting LM. GC-derived LBP activates the TLR4/NF-κB pathway to promote TGF-β1 secretion in intrahepatic macrophages, in turn, TGF-β1 activates HSCs to direct intrahepatic fibrotic PMN. Additionally, intrahepatic TGF-β1 enhances the migration and invasion of metastatic GC cells in the liverBack to article page