Fig. 7

Molecular mechanisms underlying the regulation of estrogen-related receptor alpha (ERRα) expression in pyroptosis. ERRα promotes the resistance of EC cells to pyroptosis by regulating NLRP3 inflammasomes. Platinum activates the inflammasome components, followed by the cleavage of CASP1 (Caspase 1) and production of inflammatory factors such as IL-1β and IL-18, and then triggers the cleavage of GSDMD and promotes cell membrane rupture by forming GSDMD-N. In addition, HIF-1α interacts with ERRα and enhances glycolytic metabolism in cancer cells to resist chemotherapy. Moreover, this effect might be triggered and enhanced by the hypoxic tumor microenvironment