Fig. 8

Mechanism of LMP1-induced stabilization of PGC-1α promoting invasion and metastasis of nasopharyngeal carcinoma. LMP1 promotes PRMT1-PGC-1α interaction to up-regulate the arginine methylation levels of PGC-1α. This action inhibits ubiquitination and degradation of PGC-1α, thus enhancing its protein stability. Elevated PGC-1α by LMP1 co-activates STAT3 to boost PD-L1 expression, consequently facilitating immune escape of cancer cells. These mechanisms coordinate to enhance the anoikis-resistance, invasion, and metastasis of cancer cells