Fig. 10

Schematic diagram of the mechanisms by which chronic stress remodels lung pre-metastatic niche of breast cancer. Chronic stress remodels lung pre-metastatic niche of breast cancer mainly by two ways. On one hand, chronic stress promotes production of CXCL2 chemokine in the lung, which recruits neutrophils. On the other hand, chronic stress motivates lung epithelial cells to secrete ACh that enhances NETosis of the aggregated neutrophils in the lung. The NETotic neutrophils capture the circulating tumor cells, hereby favoring lung metastasis of breast cancer. This image (AARIT33ae3) was generated by Figdraw (https://www.figdraw.com)