Table 1 Risk factors concerning AML development

Antecedent blood disorder

- Myelodysplastic syndromes

- Chronic Myeloid Leukemia

- Polycytemia Vera

- Essential Thrombocytemia

- Paroxismal Nocturnal

- Hemoglobinuria

- Aplastic Anemia

- Myelofibrosis

Genetic syndromes, family predisposition and congenital genetic lesions

- Bloom Syndrome

- Fanconi Anemia

- Kostmann Syndrome

- Wiskott-Aldrich Syndrome

- Ataxia-teleangiectasia

- Down Syndrome

- Klinefelter Syndrome

- Patau Syndrome

- Germline mutations

Chemotherapy drugs

- Alkylating agents: cyclophosphamide, melphalan, nitrogen mustard

- Topoisomerase II inhibitors: etoposide, teniposide

- Chloramphenicol

- Phenylbutazone

- Chloroquine

- Methoxypsoralen

Environmental factors and lifestyle

- Radiation exposure

- Benzene

- Smoking

- Alcohol use

- Dyes

- Herbicides

- Pesticides

- Obesity

Acquired genetic mutations

- Founder mutations

- Driver mutations