Fig. 7

The summary and hypothesis. Physical contact between osteoblasts and cancer cells is required for the dormancy induction by inactivating FAK, which enhances its nuclear translocation and reduces its phosphorylation. Dormant prostate cancer cells exhibit increased NR2F1 expression, decreased expression of MKI67 and CCND1, and reduced levels of OXPHOS-related genes such as MT-ND1 and MT-ND2. PF-271, a small molecule inhibitor of FAK, can induce dormancy in the prostate cancer cells