Fig. 1

Comparison of AutoAbs in pre-ICI collections from patients with and without irAEs G ≥ 2 and in healthy controls using different cut-offs. A cut-off of MFI 500 (circled in green) was initially selected as this represent the value at which we expect to observe reactivity with the ELISA test. Optimal cut-offs identified with ROC analysis for different classes of AutoAbs are circled in red