Fig. 3

Comparison of the level of IgM and IgG with MFI > 500 before ICI administration (baseline) and within 8 weeks from the onset of irAEs in 24 patients. A The number of elevated autoAbs before ICI is represented as a blue square (one for each patient) while the number of elevate autoAbs at the time of the irAEs is represented as a red triangle. For each patient is reported the tumor type and the type of treatment received (monotherapy vs combination). B The differences in the number of IgM and IgG with MFI > 500 are reported for different group of patients divided based on treatment received and tumor types. While a significant increase was observed in melanoma patients receiving anti-PD1 + anti-CTLA4, no significant difference was observed in the other subgroups