Fig. 1

Study design and PDOs derivation. A Overview of the procedure. B Mechanism of action or target of the drugs used in the study (blue: chemotherapies, orange: epigenetic drugs, grey: kinase inhibitors, yellow: others). C Percentage of tumor cells retrieved from core needle biopsy samples. During each biopsy procedure, several tumor samples were taken. Amongst all samples collected, 1 (e.g., CGR0030) to 4 (e.g., CGR0029) of them were assessed for cellularity. Each dot represents one core needle biopsy sample, the dots are blue when the corresponding PDO line has been successfully derived. D Average percentage of tumoral cells in the biopsy samples according to PDO establishment. E Time (in weeks) lasting from biopsy to chemogram results. Data are presented as each value and mean in C and D. Significance is determined with unpaired two-tailed t-test with Welch’s correction in D