Fig. 5
Drug response landscape across the PDOs collection. A Heatmap of scores of all 25 drugs tested on the 25 PDOs. Grey square indicates not tested. PDOs were clustered according to origin of the tumor samples (primary or metastasis). B Number of hits identified in primary tumor and metastasis derived PDO. C Percentage of hits belonging to the CRC therapeutic arsenal versus drugs with authorization in other pathologies. D Heatmap of PDO scores to each of the 25 drugs tested. PDOs were clustered according to the number of treatment lines received by the patients pre-surgery/biopsy used to generate the PDO was done. E Numbers of hits per PDO according to the number of previous treatment lines. Data are presented as a violin plot with median (dashed line), 1st and 3rd quartiles (dotted lines) in B and E. Significance is determined with unpaired two-tailed t-test with Welch’s correction in B and E