Table 1 Correlation between EZH2 and TOP2A expression and clinical characteristics in patients with HCC
Variables | Expression of EZH2 | p | Expression of TOP2A | p | ||
|---|---|---|---|---|---|---|
High (n = 188) | Low (n = 187) | High (n = 188) | Low (n = 187) | |||
Status | 0.002* | 0.042* | ||||
Alive | 106 | 135 | 111 | 130 | ||
Dead | 80 | 50 | 75 | 55 | ||
Age (years) | 0.198 | 0.032* | ||||
Age Mean (SD) | 58.5 (12.9) | 60.3 (14.0) | 57.9 (13.1) | 60.9 (13.8) | ||
Age Median [Min Max] | 59 [18,85] | 64 [16,90] | 59 [18,85] | 64 [16,90] | ||
Gender | 0.196 | 0.083 | ||||
Male | 67 | 54 | 69 | 52 | ||
Female | 119 | 131 | 117 | 133 | ||
Grade of differentiation | 0.000*** | 0.000*** | ||||
G1 | 17 | 38 | 17 | 38 | ||
G2 | 78 | 99 | 73 | 104 | ||
G3 | 78 | 44 | 84 | 38 | ||
G4 | 10 | 2 | 9 | 3 | ||
Tumor invasion | 0.002* | 0.002* | ||||
T1 | 72 | 109 | 75 | 106 | ||
T2 | 59 | 35 | 55 | 39 | ||
T3 | 48 | 32 | 48 | 32 | ||
T4 | 7 | 6 | 8 | 5 | ||
TX | 1 | 1 | ||||
Lymph node status | 0.345 | 0.264 | ||||
N0 | 130 | 122 | 131 | 121 | ||
N1 | 3 | 1 | 3 | 1 | ||
NX | 52 | 62 | 51 | 63 | ||
Distant metastasis | 0.476 | 0.586 | ||||
M0 | 137 | 129 | 135 | 131 | ||
M1 | 1 | 3 | 1 | 3 | ||
MX | 48 | 53 | 50 | 51 | ||
TNM stages | 0.024* | 0.012* | ||||
I | 69 | 102 | 15 | 38 | ||
II | 51 | 35 | 56 | 55 | ||
III | 53 | 32 | 82 | 68 | ||
IV | 1 | 4 | 18 | 20 | ||