Splicing alterations in pancreatic ductal adenocarcinoma: a new molecular landscape with translational potential

Table 2 Splicing machinery mutations found in PDAC

Splicing Machinery	Mutation	References
*SF3B1* (Splicing Factor 3b Subunit 1)	P342T L415P R625C H662Q K666R Q699_K700delinsHE K700E N763S K843R L773R K741K K946T	7 160 158 158 159 81 6, 74 81 80 6 81 160
*SF3A1* (Splicing Factor 3a Subunit 1)	S58I	7
*U2AF1* (U2 Small Nuclear RNA Auxiliary Factor 1)	A47V S34F	81 81
*U2AF2* (U2 Small Nuclear RNA Auxiliary Factor 2)		81
*SRSF1* (Serine And Arginine Rich Splicing Factor 1)		82
*PRPF40B* (Pre-MRNA Processing Factor 40 Homolog B)	L265M	7
*SF1* (Splicing Factor 1)	R380Q R662* Q269_P273del	81 81 81
*RBM6* (RNA Binding Motif Protein 6)		161
*PABPC1* (PolyA Binding Protein Cytoplasmic 1)	M158Nfs8 D165G E345 E345K L562S T319I P402L F335Lfs*19I R475Q R481C	74 4 4 4 157 7 7 7 158 158
*RBMX* (RNA Binding Motif Protein X-Linked)	D312N P106Ffs*32 A78T R341W	6 6 4 157

ISSN: 1756-9966