Splicing alterations in pancreatic ductal adenocarcinoma: a new molecular landscape with translational potential

Table 3 Altered or aberrant isoforms in PDAC

Gen	Splicing Isoform	Mechanism	References
CD44	CD44v2 CD44v6	EMT to MET transition and tumor invasiveness	90
CCK2	CCK2i4svR	Cholecystokinin and gastrin mediated pathways	97
PRLR	PRLR-SF	Proliferation, tumor growth	101
FGFR1	FGFR1-IIIb FGFR1-IIIc	Cell proliferation, adhesion, and movement	107
MUC4	MUC4/Y MUC4/YX	Cell adhesion, immune response, and cell signaling	110
BCL2L1	BCL-xL BCL-xS	Apoptosis	114
TF	flTF asTF	Blood coagulation cascade and vascularization	118
VEGFA	VEGF-111 VEGF-145	Transition from other lesions to PDAC	122
KRAS	KRAS4A KRAS4B	Cell proliferation and apoptosis	124

ISSN: 1756-9966