Fig. 8

Schematic diagram of lnc-MLETA1-based regulatory mechanism in lung cancer metastasis. Exosomal lnc-MLETA1 can be delivered from high metastatic lung cancer cells to low metastatic lung cancer cells. Moreover, lnc-MLETA1 regulates the expression of EGFR and IGF1R by sponging miR-186-5p and miR-497-5p, leading to lung cancer cell motility and metastasis