Fig. 1

The high expression of INHBB identified in GC is correlated with poor prognosis. A. Up-regulation of INHBB in digestive system cancers according to TCGA database. B-C. Overall survival and disease-free survival analysis of the GC cohort in TCGA, based on INHBB stratified expression levels (Log-rank test). D. Kaplan-Meier analysis of overall survival time with GC cohort (Log-rank test) (n = 90). E. Representative images of INHBB IHC in GC and normal tissues with different staining intensity. F. Immunohistochemistry (IHC) scores of INHBB of patient samples in GC cohort (n = 90). G-J. Association between the IHC scores of INHBB and different T stages and AJCC stages from GC cohort (n = 90). K-L. Western blot analysis of the INHBB protein levels in Ruijin GC samples (n = 8). M. qRT-PCR analysis of INHBB mRNA expression in GC and matched normal tissues (n = 20) of Ruijin GC samples. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001