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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting the M2 polarization of tumor-associated macrophages

Fig. 5

TMEM147 upregulated 27HC and led to ferroptosis resistance by promoting GPX4 expression. (a) GSH levels were assayed in the indicated erastin or RSL3 treated cells. (b) MMP changes in the indicated erastin or RSL3 treated cells. (c) Measurement of ROS in the indicated erastin or RSL3 treated cells. Scale bars, 50 μm. (d) The indicated cells were treated with erastin or RSL3 and analyzed by TEM. Scale bars: 500 nm (rows 1 and 3) and 100 nm (rows 2 and 4). (e) Representative images of subcutaneous xenograft derived from indicated HCC cells. (f) Tumors were removed from mice and subjected to immunohistochemical staining with anti-4HNE antibodies. Representative images are shown. Scale bars: 50 μm. (g) The iron metabolism-related protein level in the indicated cells. (h) GPX4 protein levels in the indicated cells. (i) GPX4 mRNA levels in the indicated cells

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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