Fig. 5

Single-cell RNA-seq analysis of SF3B4 enrichment in the HCC microenvironment. A UMAP plots depict cells in the human HCC microenvironment. B Expression of SF3B4 in each cell type. C Expression heatmap of the top 100 enriched genes in MDSC sub-clusters (C0–C5) (n = 504). D UMAP plot depicting MDSC subclusters. E Violin plot of the expression levels of SF3B4 in MDSC subclusters. F UMAP plot showing SF3B4+ and SF3B4- MDSCs. G Top 10 enriched terms in SF3B4 positive MDSC using the ‘MSigDB hallmark 2020’ database. H Gene Ontology depicts Biological Process (BP), Molecular Function (MF), and Cellular Component (CC) in SF3B4 positive MDSC