Fig. 9

Schematic diagram of the mechanism. T2-TAMs secrete exosomes rich in LINC01592 into tumor cells, and LINC01592 directly binds E2F6 and promotes E2F6 entry into the nucleus; the two synergistically promote the transcriptional level of NBR1. The increased binding of NBR1 to the ubiquitinated protein MHC-I through the ubiquitin domain mediates the increased degradation of MHC-I in autophagolysosomes and the decreased expression of MHC-I on the surface of tumor cells, which in turn leads to tumor cells escaping CD8⁺ CTL's immune attack