Fig. 7
Inhibiting lipid raft synthesis in LUAD cells impeded the tumour-promoting effects of PLPP2. a-b Effects of PLPP2 OE on cell proliferation by CCK-8 in A549 and NCI-H1299 cells, n = 3. Bars, SD; *P < 0.05, **P < 0.01; two way ANOVA. c-d Effects of PLPP2 OE on cell proliferation by colony formation assays in A549 and NCI-H1299 cells, n = 3. Bars, SD; **P < 0.01, ***P < 0.001, ****P < 0.0001; two way ANOVA. e LLC cells were fixed after infected with target lentivirus particles and IF was performed with antibodies recognizing flotillin-1 (red) and caveolin-1 (green). f Statistic analyses of flotillin-1 and caveolin-1 AOD values in LLC cells after infected with target lentivirus particles, n = 3. Bars, SD; ***P < 0.001; the student’s t test. g Subcutaneous tumour images of LLC-vector group, LLC-PLPP2 OE group, LLC-vector plus MβCD treatment group and LLC-PLPP2 OE plus MβCD treatment group in C57BL/6 mice. h Tumour growth curves derived from target groups were shown, n = 6. Bars, SD; ***P < 0.001, ****P < 0.0001; two way ANOVA