Fig. 2

Circ_0009092 inhibited proliferation, migration, and invasion of CRC cells.A-BEdU assay was performed to detect the proliferation of Lovo and HCT-116 cells.CThe colony formation activity of circ_0009092-depleted Lovo and circ_0009092-increased HCT-116 cells was evaluated by colony formation assay.DThe E-cadherin and vimentin proteins in circ_0009092 transfected CRC cells as determined by Western blot.E-FWound healing assay was used to detect the migration of circ_0009092-depleted Lovo and circ_0009092-increased HCT-116 cells.G-HThe migration and invasion ability of circ_0009092-depleted Lovo and circ_0009092-increased HCT-116 cells as detected by transwell assays. Statistical analysis between two groups was performed using two-tailed t-test. One-way ANOVA statistical tests were adopted for more than two groups. Data are the means ± SD of three experiments. *P< 0.05, **P< 0.01, ***P< 0.001