Fig. 5
GDNPs relieved T cell exhaustion by enhancing the effecting function of CD8 Teff. a UMAP embedding showed expression levels of Cd8a of T cells indicated in panel. b UMAP showing the composition of T cells colored by cluster. c Heatmap showed the expression of genes in four modules of cvtotoxicity, chemokine, naive and inhibitory receptor in CD8 + T cells subclusters (naive T, CD8 Teff and CD8 Tex) in G (GDNPs) and V (Vehicle) groups. d, e, f Ucell scores were performed for gene sets with effector characteristics in three CD8 + T cells subclusters. g Heatmap showed transcription factor (Tox, Eomes, Tbx21) expression in T cell subsets in groups G and V. All results represent the mean ± SEM (n = 3). Wilcox (d, e, f) was used to compare results of different experimental groups for statistically significant difference (****P < 0.0001)