Fig. 6

Assessment of in vivo killing of UniCAR T-cells redirected by αFAP TMs. Female NXG mice were injected with either HT1080 hFAP Luc cells (orange), HT1080 hFAP Luc cells and UniCAR T-cells (blue), or HT1080 hFAP Luc cells and UniCAR T-cells in combination with either αFAP-scFv (black) or –IgG4 TM (grey). a the bioluminescence signals of the HT1080 hFAP cells in all groups were monitored for 10 days. b based on the luminescence imaging results obtained, a quantitative analysis was performed and are represented as mean ± SD for 5 individual mice. Statistical relevance was calculated using two-way ANOVA and Dunnett multiple-comparison test with respect to the control group injected with HT1080 hFAP Luc cells alone