Fig. 16From: Caloric restriction and metformin selectively improved LKB1-mutated NSCLC tumor response to chemo- and chemo-immunotherapyTME and spleen immune characterization of K and KL untreated mice: A, B TME immune profile of KRASG12D and KRASG12D/LKB1del tumours injected intramuscularly; C, D spleen immune profile of immunocompetent mice bearing KRASG12D and KRASG12D/LKB1del tumours; samples from the experiment in Fig. 12 were collected and processed for FACS analysis of lymphoid and myeloid infiltrating immune cells (see Fig. 2 for the gate strategy). One-way and two-way ANOVA were used for statistical analysis (**p < 0.01, ****p < 0.0001). Error bars indicate SDBack to article page