Fig. 9

Schematic illustrating the role of PHB2 in regulating GC tumorigenesis. SHIP2 acts as a negative regulator of phosphoinositide 3-kinase (PI3K) and insulin signaling. In GC cells, high expression of PHB2 enhanced the interaction between NEDD4 and SHIP2, which triggers the ubiquitination degradation of SHIP2, consequently leading to the activation of Akt and promoting GC proliferation and tumorigenesis