Fig. 2

Predicted 3D conformation of TAA and microbiota-derived paired peptides and peptide-TCR interaction. The surface conformation of the most similar paired HLA-A*02:01 restricted TAA and MoAs-derived peptides is shown. Residues in the microbiota-derived epitopes (FIRM = firmicutes; BACT = bacteroidetes) that differs from the TAA sequences are indicated in red color. Red areas = contact points with HLA-A molecule; blue areas = contact points with TCR α chain; Light Blue = contact points with TCR β chain. The images below the peptides show the contact sites with α and β chains of TCR (yellow areas)