Fig. 7
From: PELI1: key players in the oncogenic characteristics of pancreatic Cancer
PELI1 Promotes PI3K/Akt/GSK3β Pathway Activation through RPS3. A KEGG enrichment analysis indicates the potential association of PELI1 with the PI3K/Akt pathway. B PELI1 promotes the phosphorylation of key proteins in the PI3K/Akt/GSK3β pathway. C Treatment with the PI3K inhibitor LY294002 and overexpression of RPS3 lead to a reduction in the phosphorylation of key proteins in the PI3K/Akt/GSK3β pathway. D, E The effects of RPS3 on PC cell proliferation assessed by CCK-8 (D), clone formation (E). F Effects of RPS3 on PC cell metastasis and invasion were examined by Transwell assay. G Multiplex fluorescence IHC assesses protein expression of PELI1, RPS3, and Akt in PC and paracancerous tissues. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001