Fig. 4

Predictive signatures for Auranofin response. A Clustered heatmap of the top 25 negative (cluster S1) and top 25 positive (cluster S2) correlated genes with the normalized Area Over the Curve (AOC) values of the fitted dose–response curves for Auranofin in 9 organoid lines, excluding PDAC_087. B Functional annotation of cluster S1 for the Hallmark geneset collection. C-D Volcano plots and normalized enrichment score (NES) of the predictive signatures derived from significantly (p < 0.01) positive (n = 86) and negative correlated genes (n = 128) for PDAC_087 versus the sensitive, intermediate and resistant organoids